|
KMID : 1161920200170030080
|
|
Journal of Medicine and Life Science
2020 Volume.17 No. 3 p.80 ~ p.85
|
|
|
Treatment of severe sepsis and septic shock associated with urogenital tract infection
|
|
Hwang Kyu-Bin
Huh Jung-Sik
Kim Young-Joo
Park Kyung-Kgi
Kim Sung-Dae
You Hyun-Wook
|
|
|
Abstract
|
|
|
|
Urinary tract infections are among the most common infectious diseases and are the major causes of mortality and morbidity. These diseases result in many severe hospitalizations each year. Severe sepsis and septic shock are common and life-threatening medical conditions, and large cases are associated with urinary tract infection. The medical term “severe sepsis” is defined as sepsis complicated by hypotension, organ dysfunction, and tissue hypoperfusion, whereas “septic shock” is defined as sepsis complicated either by hypotension that is refractory to fluid resuscitation or by hyperlacteremia. A recent multicenter-study in Korea reported that the rate of in-hospital mortality associated with severe sepsis and septic shock was >34%. Among the causative diseases, urogenital tract infection showed a high correlation. Moreover, it is very important that clinicians detect severe sepsis and septic shock early and treat them properly. The principles of initial treatment include provision of sufficient hemodynamic resuscitation and early administration of appropriate antibiotic therapy to mitigate uncontrolled infection. Initial resuscitation includes the use of vasopressors and intravenous fluids, and it is a key to achieve the target of initial resuscitation. Supportive care in the intensive care unit, such as glucose control, stress ulcer prophylaxis, blood transfusion, deep vein thrombosis prophylaxis, and renal replacement therapy, is also significant. We have summarized the key components in the treatment of severe sepsis and septic shock in patients with urinary tract infection. Urologists should be aware that appropriate early treatment is necessary to prevent fatal outcomes in these patients.
|
|
|
KEYWORD
|
|
|
Sepsis, infection, Urinary tract, Treatment
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|